Guidelines for Anaplasmosis Vaccination

Please read and follow our guidelines for anaplasmosis vaccination. These tips will help prevent the spread of anaplasmosis, prevent waste, and improve the efficiency of this vaccine.

• Our anaplasmosis vaccine is administered as a 1 cc dose, which should be given subcutaneously in the neck only.
• The vaccine protocol requires two doses in the first year, with one annual booster given each subsequent year. The second dose should be administered four weeks after the first dose. It is important to note that it takes time for the immune system to develop protection; animals should achieve good protective immunity within 7 to 10 days following the second injection.

• This vaccine is a killed vaccine and maintains stability at environmental temperatures, so shipping on ice is not necessary.
• The vaccine vial remains sterile until opened. After opening, mold spores from the air may contaminate the remaining vaccine. Therefore, Any unused vaccine should be refrigerated after the vial has been opened.

• A 3-cc syringe is necessary to accurately deliver the 1 cc dose, as larger syringes may not provide accurate dosing and can result in vaccine waste.
• To prevent contamination, insert 1 sterile needle into the vial and use this needle to draw all doses. This practice helps avoid introducing Anaplasma into the vial, reducing the risk of transmission to other cattle in the herd.
• Always use a sterile needle for each animal. If blood is observed on the hub of the syringe after removing the needle, discard it and use a new sterile syringe. Neglecting this step could spread anaplasmosis and other diseases. Needles and syringes can be safely cleaned by boiling or autoclaving for 20 minutes, then allowed to air dry and stored in a sterile environment for reuse.

• If you suspect an animal is incubating anaplasmosis during vaccination, you may inject Tetracycline at a different site without affecting the vaccine’s effectiveness.
• Our vaccine is safe for use at any stage of pregnancy, with no reported cases of Neonatal Isoerythrolysis (NI) in calves from vaccinated cows.
• It is critical to monitor your herd for signs of anaplasmosis until the immune system develops the necessary protection, typically within 7 to 10 days following the second injection.
• Keep in mind that no vaccine guarantees 100% protection. Vaccine failures can occur for various reasons, often related to the health of the vaccinated animal rather than the vaccine itself. Factors that may lead to vaccine breaks include:
  • There are multiple strains of anaplasmosis in the USA and worldwide.
  • Our vaccine utilizes the Anaplasmosis Mississippi Strain of Anaplasma marginale, which appears to cross-protect against most, if not all, strains in the USA and many regions globally.

For effective vaccination, the animal must have a healthy immune system. Older animals may have compromised immunity, which affects their response to vaccines. Additionally, younger animals can have weakened immune systems due to certain diseases, particularly viral infections, impacting their response to the vaccine antigens.

Our vaccine is dispensed aseptically into sterile vials, with an approximate 10% overfill included in each vial to facilitate priming the recommended 3 cc syringe. Please be aware that water deprivation can severely compromise the immune system, hindering the vaccine’s ability to stimulate an effective immune response in both young and older animals.

Click for Printable PDF Link of Vaccine Insert